Determining the potency of neuromuscular blockers

Neuromuscular Blockers PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION Anatomy of the Neuromuscular Junction

the structure was established by King in 1935, however, one of the nitrogen groups was later found to be tertiary a synthetic analogue, metocurine, was developed several years later with 3x the potency of dTC gallamine, another of the series, was synthesised about 1950 NB: in 1954 Beecher & Todd published their multi-institutional report which showed a 6-fold increase in mortality with the use ...

Potentiationof Neuromuscular by CalciumChannel Blockade Blockers

A significant reduction was noticed in the amount of vecurenium needed to maintain steady neuromuscular blockade at 20% twitch height (Tl> in patients given nicardipine intraoperatively. Bolus ajection of either nicardipine or d.iltlazem during constant infusion of yecuronium produced transient depression of Tl and the train-offour ratio CTOFR). Reversal of neuromuscular blockade wtth a choline...

Sevoflurane enhances neuromuscular blockade by increasing the sensitivity of skeletal muscle to neuromuscular blockers.

The aim of this study was to investigate the effects of sevoflurane on skeletal muscle contractility. In the first part, twenty-two American Society of Anesthesiology (ASA I-II) female adult patients undergoing elective hysterectomy surgery inhaled sevoflurane 1.0, 1.5 and 2.0 minimum alveolar concentrations (MAC) in succession. Neuromuscular function was assessed at each dose. In the second pa...

theoretical study on molecular orbital energy levels of h-2 blockers and correlation to their potency

Neuromuscular blockers in early acute respiratory distress syndrome.

BACKGROUND In patients undergoing mechanical ventilation for the acute respiratory distress syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease ventilator-induced lung injury but may also cause muscle weakness. We evaluated clinical outcomes after 2 days of therapy with neuromuscular blocking agents in patients with early, severe ARDS. METHODS In this multicent...